MUSK Mouse Monoclonal Antibody
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AMM4593-61 50ul 1500.00 In Stock
AMM4593-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 4593
Isotype: IgG1 Swiss Prot: O15146
purity: Affinity chromatography
Background:
MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
Reactivity Human
Tested applications IHC ELISA ICC
Clonality Monoclonal Antibody
Calculated MW 97 kDa
Recommended Dilutions
IHC 1:200-1:1000
ICC 1:200-1:1000
Immunogen A purified recombinant fragment of human MUSK expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym muscle, skeletal, receptor tyrosine kinase
This product is for research use only, not for diagnostic or therapeutic use!

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