| No | Size | Price | Availability | |
| AMM3678-61 | 50ul | 1500.00 | In Stock |  |
| AMM3678-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 3678 |
| Isotype: | IgG1 | Swiss Prot: | P08648 |
| purity: | Affinity chromatography |
| Background: |
| The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues. |
| Reactivity | Human |
| Tested applications | WB IHC ELISA FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 114 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human ITGA5 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FNRA, CD49e, VLA5A, ITGA5receptor subunit alphaIntegrin alpha-FVLA-5CD49e antigen |
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