Source: | Mouse | Gene Id: | 81651(Rat) |
Isotype: | IgG1 | Swiss Prot: | Q8VHY0 |
purity: | Affinity purification |
Background: |
Cspg4 (also known as melanoma-associated chondroitin sulfate proteoglycan 4, NG2, MCSP, MCSPG, MSK16 and MEL-CSPG) stabilizes cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. Cspg4 may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion and growth. Threonine 2256 phosphorylation of rat Cspg4 (Threonine 2252 phosphorylation of human Cspg4) leads to redistribution of Cspg4 on the surface of astrocytomas, polarization of the cell and a significant increase in cell motility. Cspg4 acts as a co-receptor for spreading and focal contact formation in association with ?4 ∫1 integrin in malignant melanoma cells. Cspg4 is present on blood vessels throughout the rat embryo. Microvessels within the rat CNS express Cspg4 on endothelial cells, and outside the CNS, Cspg4 is present on smooth muscle cells. Cspg4 is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering. |
Reactivity | Rat |
Tested applications | WB IP IF |
Clonality | Monoclonal Antibody |
Calculated MW | 270-300 kDa |
Recommended Dilutions |
WB 1:100-1:1000
IF 1:50-1:500
|
Immunogen | A truncated integral membrain form of Cspg4 consisiting of amino acids 1592-2222 |
Storage | Store at 4°C in PBS with 0.1% gelatin and 0.1% sodium azide. Do not freeze. |
Synonym | AN2, NG2, 4732461B14Rik |
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