| No | Size | Price | Availability | |
| HRM142C-21S | 50ul | 1500.00 | In Stock |  |
| HRM142C-21S | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 142 |
| Isotype: | IgG1 | Swiss Prot: | P09874 |
| purity: | Affinity purification |
| Background: |
| PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6).(This product is sold under license from Promega Corp., U.S. Patent No. 6,350,452.) |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 89 kDa |
| Recommended Dilutions |
WB 1:2000
|
| Immunogen | A synthetic PARP peptide corresponding to carboxy-terminal residues surrounding Asp214 in human PARP |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1 |
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