| No | Size | Price | Availability | |
| ARM4088P-21 | 50ul | 1500.00 | In Stock |  |
| ARM4088P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4088 |
| Isotype: | IgG | Swiss Prot: | P84022 |
| purity: | Affinity purification |
| Background: |
| Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-β/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions. Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-β), an inhibitor for tumor cell proliferation. Smad3 is activated by activin/TGF-β receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF- β target genes. Interaction of Smad3 with Akt, can initiate TGF- β induced apoptosis and cell cycle arrest. Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IP ChIP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 52 kDa |
| Recommended Dilutions |
WB 1:1000
ChIP 1:100
Dot 1:100
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser423/425 of Smad3 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 |
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