| No | Size | Price | Availability | |
| ARM841C-21 | 50ul | 1500.00 | In Stock |  |
| ARM841C-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 841 |
| Isotype: | IgG | Swiss Prot: | Q14790 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq |
| Reactivity | Human |
| Tested applications | WB IHC IF FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 18, 41, 43 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:100
IF 1:100
FC 1:100
|
| Immunogen | A synthetic peptide corresponding to residues adjacent to Asp391 of human Caspase-8 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473, Caspase8 |
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