ARM841C-21 [Monoclonal Antibody]
Cleaved CASP8 (Asp391) Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF FC
Immunogen Range:   A synthetic peptide corresponding to residues adjacent to Asp391 of human Caspase-8
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   841
Swiss Prot:   Q14790
Synonyms:   ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473, Caspase8
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
Caculated MW:   18, 41, 43 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:100
IF 1:100
FC 1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information