| Source: | Rabbit | Gene Id: | 9641 | 
| Isotype: | IgG | Swiss Prot: | Q14164 | 
| purity: | Affinity purification | 
| Background: | 
| IKK epsilon is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. It has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (1). IKK epsilon phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It plays a special role in the immune response. IKK epsilon protects cells against DNA damage-induced cell death (2). | 
| Reactivity | Human | 
| Tested applications | WB IP | 
| Clonality | Monoclonal Antibody | 
| Calculated MW | 80 kDa | 
| Recommended Dilutions | WB 1:1000 | 
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser172 of human IKKε protein | 
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. | 
| Synonym | IKBKE, IKK-E, IKK-i, IKKE, IKKI, KIAA0151, MGC125294, MGC125295, MGC125297 | 
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