ARM9641P-21
[Monoclonal Antibody]
Phospho-IKBKE-Ser172 Rabbit Monoclonal Antibody
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DATASHEET
Species: |
Rabbit |
Applications: |
WB IP |
Immunogen Range: |
A synthetic phosphopeptide corresponding to residues surrounding Ser172 of human IKKε protein |
Clonality: |
Monoclonal Antibody |
Isotype: |
IgG |
GENE ID: |
9641 |
Swiss Prot: |
Q14164 |
Synonyms: |
IKBKE, IKK-E, IKK-i, IKKE, IKKI, KIAA0151, MGC125294, MGC125295, MGC125297 |
Purification: |
Affinity purification |
Storage: |
Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Background: |
IKK epsilon is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. It has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (1). IKK epsilon phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It plays a special role in the immune response. IKK epsilon protects cells against DNA damage-induced cell death (2). |
Caculated MW: |
80 kDa |
Observed MW: |
Refer to Figures |
Applications: |
WB 1:1000
|
Reacitivity: |
Human |
For research use only. Not intended for diagnostic or therapeutic use!