LMNA Mouse Monoclonal Antibody (Alexa Fluor(R) 488 Conjugate)
No Size Price Availability  
AMM4000-21C 50ul 1500.00 In Stock
AMM4000-21C 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 4000
Isotype: IgG2a Swiss Prot: P02545
purity: Affinity purification
Background:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Reactivity Human, Monkey, Mouse, Rat
Tested applications IF FC
Clonality Monoclonal Antibody
Calculated MW /
Recommended Dilutions
IF 1:50
FC 1:50
Immunogen A recombinant fragment of human lamin A protein
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
This product is for research use only, not for diagnostic or therapeutic use!

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