P4HB Rabbit Monoclonal Antibody (Alexa Fluor(R) 594 Conjugate)
No Size Price Availability  
ARM5034P-23C 50ul 1500.00 In Stock
ARM5034P-23C 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5034
Isotype: / Swiss Prot: P07237
purity: Affinity purification
Background:
During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds (1). This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds (2). Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange (3). This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins (3).
Reactivity Human, Monkey, Mouse, Rat
Tested applications IF
Clonality Monoclonal Antibody
Calculated MW 57 kDa
Recommended Dilutions
IF 1:50
Immunogen A synthetic peptide corresponding to the sequence of human PDI protein
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym P4HB, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
This product is for research use only, not for diagnostic or therapeutic use!

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