| No | Size | Price | Availability | |
| ARMF016-21 | 50ul | 1500.00 | In Stock |  |
| ARMF016-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10236/10492 |
| Isotype: | IgG | Swiss Prot: | O60506/O43390 |
| purity: | Affinity purification |
| Background: |
| Heterogeneous nuclear ribonucleoprotein Q and R belong to a family of hnRNP proteins that are involved in RNA binding, RNA biosynthesis, and mRNA transport from the nucleus to the cytoplasm (1-3). These two proteins are encoded by different genes but have 83% homology. hnRNP Q has three alternative splice variants (hnRNP Q1-3) (1-3). Methylation of carboxy-terminal arginine residues is required for nuclear localization (4). hnRNP Q binds to AU-rich mRNA in conjunction with AUF1 and regulates mRNA decay (5). hnRNP Q isoforms play a crucial role in mediating nuclear function of survival of motor neuron (SMN) complex (6,7) and modulating RNA biosynthesis and hepatitis C virus replication (8). hnRNP R was identified recently and its function is still under investigation (9), however hnRNP R does not duplicate the biological function of hnRNP Q. Both hnRNP Q and R are present in cytoplasmic mRNP granules containing untranslated mRNAs (10) and both interact with SMN (11). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 65-82 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Lys371 of human hnRNP Q protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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