| No | Size | Price | Availability | |
| ARM1026-23C | 50ul | 1500.00 | In Stock |  |
| ARM1026-23C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1026 |
| Isotype: | IgG | Swiss Prot: | P38936 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq |
| Reactivity | Human, Monkey |
| Tested applications | IF FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 21 kDa |
| Recommended Dilutions |
IF 1:50
FC 1:50
|
| Immunogen | A synthetic peptide corresponding to residues near the carboxy terminus of human p21 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 |
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