| No | Size | Price | Availability | |
| ARM7791P-21 | 50ul | 1500.00 | In Stock |  |
| ARM7791P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7791 |
| Isotype: | IgG | Swiss Prot: | Q15942 |
| purity: | Affinity purification |
| Background: |
| The zyxin family of proteins includes LIMD1, ajuba, trip6 and zyxin, each of which contains three LIM domains at the carboxy-terminus. Zyxin family members associate with the actin cytoskeleton and are components of both the cell-cell junction adhesive complex and the integrin-mediated adhesive complex. They shuttle in and out of the nucleus where they may function in transcriptional activation (1).Zyxin is involved in the regulation of mechanical force-induced actin polymerization at focal adhesions (2), and in regulation of adhesion and migration, possibly through recruitment of Ena/VASP proteins to focal adhesions (3). Zyxin interacts with and may regulate the function of the tumor suppressor myopodin, which inhibits tumor growth and metastasis (4). |
| Reactivity | Human, Monkey, Mouse, Rat, Dog |
| Tested applications | WB IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 78 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Ser142 and Ser143 of human zyxin protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Zyxin, ESP-2, HED-2 |
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