Source: | Rabbit | Gene Id: | / |
Isotype: | IgG | Swiss Prot: | / |
purity: | Affinity purification |
Background: |
An important class of kinases, referred to as Arg-directed kinases or AGC-family kinases, includes cAMP-dependent protein kinase (PKA), cGMP-dependent protein kinase (PKG), protein kinase C, Akt, and RSK. These kinases share a substrate specificity characterized by Arg at position -3 relative to the phosphorylated Ser or Thr (1,2). Akt plays a central role in mediating critical cellular responses including cell growth and survival, angiogenesis, and transcriptional regulation (3-5). While a number of Akt substrates are known (such as GSK-3, Bad, and caspase-9) many important substrates await discovery. Akt phosphorylates substrates only at Ser/Thr in a conserved motif characterized by Arg at positions -5 and -3 (6). |
Reactivity | D. melanogaster, Mouse, All |
Tested applications | WB |
Clonality | Monoclonal Antibody |
Calculated MW | / |
Recommended Dilutions |
WB 1:1000
|
Immunogen | A synthetic phospho-Akt substrate peptides |
Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | / |
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