Non-phospho-PTPN5-Ser221 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM84867NP-21 50ul 1500.00 In Stock
ARM84867NP-21 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 84867
Isotype: IgG Swiss Prot: P54829
purity: Affinity purification
Background:
Striatal enriched phosphatase (STEP, also known as PTPN5), is a protein tyrosine phosphatase expressed in dopaminoceptive neurons of the central nervous system (1). Alternative splicing produces the cytosolic STEP46 and the membrane-associated STEP61 isoforms of STEP. Dopamine activates D1 receptors and PKA, which in turn phosphorylate both isoforms of STEP. Phosphorylation of STEP61 occurs at Ser160 and Ser221, while STEP46 is phosphorylated at Ser49 (equivalent to Ser221 of STEP61) (2). NMDA-mediated activation of STEP is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, STEP is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). Due to its importance in cognitive function, STEP may play a role in Alzheimer's disease (1).
Reactivity Human, Mouse, Rat
Tested applications WB IP IF
Clonality Monoclonal Antibody
Calculated MW 46, 61 kDa
Recommended Dilutions
WB 1:1000
IF 1:50
Immunogen A synthetic nonphosphopeptide corresponding to residues surrounding Ser221 of human STEP61 protein
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym FLJ14427, PTPSTEP, STEP
This product is for research use only, not for diagnostic or therapeutic use!

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