RICTOR Rabbit Monoclonal Antibody (Sepharose Bead Conjugate)
No Size Price Availability  
ARM253260-21C 50ul 1500.00 In Stock
ARM253260-21C 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 253260
Isotype: IgG Swiss Prot: Q6R327
purity: Affinity purification
Background:
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1, and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4).
Reactivity Human, Mouse
Tested applications IP
Clonality Monoclonal Antibody
Calculated MW 200 kDa
Recommended Dilutions
Immunogen A synthetic peptide corresponding to the sequence around Leu1121 of human rictor protein
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym DKFZp686B11164, KIAA1999, MGC39830, mAVO3
This product is for research use only, not for diagnostic or therapeutic use!

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