| No | Size | Price | Availability | |
| ARM1956-21SC | 50ul | 1500.00 | In Stock |  |
| ARM1956-21SC | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1956 |
| Isotype: | IgG | Swiss Prot: | P00533 |
| purity: | Affinity purification |
| Background: |
| The epidermal growth factor (EGF) receptor is a 170 kDa transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Research studies have shown that somatic mutations in the tyrosine kinase domain of EGF receptor (EGFR) are present in a subset of lung adenocarinomas that respond to EGFR inhibitors, such as gefinitib and erlotinib (1-3). Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, that occurs in exon 21 and short in-frame deletions in exon 19 (4,5). The most frequent exon 19 deletion is E746-A750, accounting for 90% of lesions at this site, although some rare variants occur. |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 175 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to L858R mutant sequence of human EGF receptor |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ERBB, ERBB1, HER1, PIG61, mENA |
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