Phospho-ERBB3-Tyr1222 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM2065P-22 50ul 1500.00 In Stock
ARM2065P-22 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 2065
Isotype: IgG Swiss Prot: P21860
purity: Affinity purification
Background:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Reactivity Human
Tested applications WB
Clonality Monoclonal Antibody
Calculated MW 185 kDa
Recommended Dilutions
WB 1:1000
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr1222 of human HER3/ErbB3
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3
This product is for research use only, not for diagnostic or therapeutic use!

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