CAMK2 Rabbit Monoclonal Antibody
No Size Price Availability  
ARMF056-21 50ul 1500.00 In Stock
ARMF056-21 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 815/816/817/818
Isotype: IgG Swiss Prot: Q9UQM7 Q13554 Q13557 Q13555
purity: Affinity purification
Background:
CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T cell receptor signaling (1,2). CaMKII has catalytic and regulatory domains. Ca2+/calmodulin binding to the CaMKII regulatory domain relieves autoinhibition and activates the kinase (3). The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active (3). The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286. PKA (protein kinase A) prevents phospho-CaMKII (Thr286) dephosphorylation through an inhibitory effect on PP1 (4).
Reactivity Human, Mouse, Rat
Tested applications WB
Clonality Monoclonal Antibody
Calculated MW 60, 50 kDa
Recommended Dilutions
WB 1:1000
Immunogen A synthetic peptide surrounding Val184 of human CaMKII-alpha
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym /
This product is for research use only, not for diagnostic or therapeutic use!

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