Source: | Rabbit | Gene Id: | 93759(Mouse) |
Isotype: | IgG | Swiss Prot: | Q923E4 |
purity: | Affinity purification |
Background: |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq |
Reactivity | Mouse |
Tested applications | WB IP |
Clonality | Monoclonal Antibody |
Calculated MW | 120 kDa |
Recommended Dilutions |
WB 1:1000
|
Immunogen | A synthetic peptide corresponding to the carboxy terminus of mouse SirT1 |
Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | Sir2, Sir2a, SIR2L1, AA673258, Sir2alpha |
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