| No | Size | Price | Availability | |
| ARM1978P-23C | 50ul | 1500.00 | In Stock |  |
| ARM1978P-23C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1978 |
| Isotype: | IgG | Swiss Prot: | Q13541 |
| purity: | Affinity purification |
| Background: |
| Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2,3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5). |
| Reactivity | D. melanogaster, Human, Monkey, Mouse, Rat |
| Tested applications | WB FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 15 to 20 kDa |
| Recommended Dilutions |
WB 1:1000
FC 1:400
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr37 and Thr46 of mouse 4E-BP1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | 4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I |
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