| No | Size | Price | Availability | |
| ORM15163-21S | 50ul | 1500.00 | In Stock |  |
| ORM15163-21S | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 15163(Mouse)/288077(Rat) |
| Isotype: | IgG | Swiss Prot: | P49710 |
| purity: | Affinity purification |
| Background: |
| HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7). |
| Reactivity | Mouse, Rat |
| Tested applications | WB IHC IP FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 80 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:100
FC 1:100
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Leu310 of mouse HS1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HS1, AW213261 |
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