HCLS1 Rabbit Monoclonal Antibody (Human Specific)
No Size Price Availability  
HRM3059-21S 50ul 1500.00 In Stock
HRM3059-21S 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 3059
Isotype: IgG Swiss Prot: P14317
purity: Affinity purification
Background:
HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7).
Reactivity Human
Tested applications WB IHC IP IF FC
Clonality Monoclonal Antibody
Calculated MW 80 kDa
Recommended Dilutions
WB 1:1000
IHC 1:100
IF 1:200
FC 1:200
Immunogen A synthetic peptide corresponding to residues surrounding Pro310 of human HS1
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CTTNL, HS1
This product is for research use only, not for diagnostic or therapeutic use!

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