| No | Size | Price | Availability | |
| ARM3791P-21 | 50ul | 1500.00 | In Stock |  |
| ARM3791P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3791 |
| Isotype: | IgG | Swiss Prot: | P35968 |
| purity: | Affinity purification |
| Background: |
| Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8). |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 230 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr1214 of human VEGF receptor-2 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FLK1, CD309, VEGFR, VEGFR2 |
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