| No | Size | Price | Availability | |
| AMM4856-21 | 50ul | 1500.00 | In Stock |  |
| AMM4856-21 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 4855 |
| Isotype: | IgG1 | Swiss Prot: | Q9UM47 |
| purity: | Affinity purification |
| Background: |
| Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4).Notch4 is primarily expressed in endothelial cells and is processed similarly to Notch1 (5-7). The mouse Notch4 gene (also known as Int-3) is a frequent target in Mouse Mammary Tumour Virus (MMTV)-induced mammary tumors (6,8). The intracellular domain of Notch4 binds to Smad3 and inhibits TGF-β signaling (9). |
| Reactivity | Human |
| Tested applications | WB IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 244 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A recombinant protein consisting of the Ankyrin repeat domain of human Notch4 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CASIL, CADASIL |
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