| No | Size | Price | Availability | |
| ORM21926-21S | 50ul | 1500.00 | In Stock |  |
| ORM21926-21S | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 21926(Mouse)/24835(Rat) |
| Isotype: | IgG | Swiss Prot: | P06804/P16599 |
| purity: | Affinity purification |
| Background: |
| TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein (1,2). Membrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer (2). Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages (1). Cellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk1/2, p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell death (1,2). TNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosis (3). |
| Reactivity | Mouse |
| Tested applications | WB IP IF FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 17,25,28 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:400
FC 1:100
|
| Immunogen | A recombinant mouse TNF-α protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DIF, Tnfa, TNF-a, TNFSF2, Tnfsf1a, TNFalpha, TNF-alpha |
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