PTPRC Mouse Monoclonal Antibody
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AMM5788-15 50ul 1500.00 In Stock
AMM5788-15 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 5788
Isotype: IgG2b Kappa Swiss Prot: P08575
purity: Protein G purification
Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Reactivity Human
Tested applications ELISA FC
Clonality Monoclonal Antibody
Calculated MW 180-240 kDa
Recommended Dilutions
Immunogen A recombinant protein corresponding to amino acids 1029-1249 of human PTPRC
Storage Store at -20°C in PBS, pH 7.4 (0.1% sodium azide).Avoid freeze/thaw cycles.
Synonym B220, CD45, CD45R, GP180, LCA, LY5, T200
This product is for research use only, not for diagnostic or therapeutic use!

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