PARVA Rabbit Monoclonal Antibody
No Size Price Availability  
ARM55742-11 50ul 1500.00 In Stock
ARM55742-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 55742
Isotype: IgG Swiss Prot: Q9NVD7
purity: Affinity purification
Background:
The extracellular matrix (ECM) is a complex structure of secreted macromolecules surrounding mammalian organs and tissues. Controlled interactions between cells and the ECM are important in proliferation, migration, survival, polarity, and differentiation. Cells contact the ECM primarily through heterodimeric integral membrane proteins called integrins. Integrins connect the ECM to the cytoskeleton, and therefore the cell signaling machinery, through protein complexes called focal adhesions. The ILK/PINCH/Parvin (IPP) complex is composed of three highly conserved proteins recruited to sites of ECM contact as pre-assembled structures. The IPP acts at the interface of the integrin/actin connection to regulate formation of focal adhesions and integrin signaling. All three proteins contain multiple protein binding domains allowing them to function as adaptor proteins in the formation of focal adhesions. ILK (integrin-linked kinase) also has a catalytic (protein Ser/Thr kinase) domain, and may or may not function as a kinase in vivo. Roles for IPP proteins outside of the IPP complex have been proposed, including regulation of gene expression. The parvin family consists of 3 members, α-parvin/actopaxin, β-parvin/affixin, and γ-parvin. α-parvin and β-parvin are expressed ubiquitously, while expression of γ-parvin is restricted to hematopoietic cells. α-parvin binds to f-actin both directly and via interaction with the focal adhesion protein paxillin. α-parvin regulates cell spreading and motility through interactions with the cofilin kinase TESK1, and with the GTPase activating protein CdGAP. Phosphorylation of α-parvin during mitosis may have a role in the regulation of actin dynamics during the cell cycle.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 43 kDa
Recommended Dilutions
Immunogen A synthetic peptide of human PARVA is used for rabbit immunization
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym FLJ10793, FLJ12254, MXRA2
This product is for research use only, not for diagnostic or therapeutic use!

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