| No | Size | Price | Availability | |
| ARM23184-11 | 50ul | 1500.00 | In Stock |  |
| ARM23184-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 23184 |
| Isotype: | IgG | Swiss Prot: | Q14696 |
| purity: | Affinity purification |
| Background: |
| Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7. MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6. MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling. The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass. |
| Reactivity | Human |
| Tested applications | WB ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 25, 26 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic peptide of human MESDC2 is used for rabbit immunization |
| Storage | Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles. |
| Synonym | BOCA, KIAA0081, MESD |
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