PASK Mouse Monoclonal Antibody
No Size Price Availability  
AMM23178-12 50ul 1500.00 In Stock
AMM23178-12 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 23178
Isotype: IgM Kappa Swiss Prot: Q96RG2
purity: Affinity purification
Background:
PASK is a serine/threonine kinase that contains two PAS (Per-Arnt-Sim) domains. Its kinase activity is up-regulated by autophosphorylation of the activation loop within its catalytic domain and is inhibited in cis by one of the PAS domains. Studies found that the yeast homolog of PASK phosphorylates and inhibits two enzymes required for glycogen biosynthesis: UDP-glucose pyrophosphorylase and glycogen synthase, resulting in the decrease of carbohydrate storage. Further studies showed that increased glucose levels activate PASK activity and enhance its expression in pancreatic β-cells. PASK is essential for the glucose-stimulated expression of preproinsulin and Pdx1, suggesting its role in the regulation of genes involved in pancreatic β-cell functions. PASK was shown to be critical for glucose-stimulated insulin secretion in pancreatic β-cells. The absence of PASK also protects animals from obesity and insulin resistance when they are fed a high-fat diet. These findings suggest that PASK functions as an important metabolic sensor in various cells.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 170 kDa
Recommended Dilutions
Immunogen PASK (AAH63585, 1 aa ~ 100 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in ascites fluid. Avoid freeze/thaw cycles.
Synonym DKFZp434O051, DKFZp686P2031, KIAA0135, PASKIN, STK37
This product is for research use only, not for diagnostic or therapeutic use!

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