ZNF259 Mouse Monoclonal Antibody
No Size Price Availability  
AMM8882-11 50ul 1500.00 In Stock
AMM8882-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 8882
Isotype: IgG2a Kappa Swiss Prot: O75312
purity: Affinity purification
Background:
The zinc finger protein ZPR1 (ZNF259) binds to epidermal growth factor receptor (EGFR) and is localized to both cytoplasm and nucleus. The zinc fingers found in ZPR1 and the tyrosine kinase domain of EGFR mediate the interaction between ZPR1 and the receptor. ZPR1 translocates from the cytoplasm to nucleus following mitogen (i.e. EGF) stimulation. ZPR1 also interacts with translation elongation factor eEF1A in vivo following EGF treatment. The interaction between the zinc finger protein and elongation factor is important for cell proliferation. Cells lacking ZPR1 exhibit abnormal nucleolar function, suggesting that ZPR1 is required for cell viability and nucleolar function in dividing cells. ZPR1 knockout mice exhibit significant neurodegeneration, and reduced or altered expression of ZPR1 may contribute to spinal muscular atrophy, a disorder characterized by degeneration of spinal cord neurons.
Reactivity Human
Tested applications WB IHC S-ELISA ELISA
Clonality Monoclonal Antibody
Calculated MW 51 kDa
Recommended Dilutions
Immunogen ZNF259 (NP_003895, 361 aa ~ 459 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym MGC110983, ZPR1
This product is for research use only, not for diagnostic or therapeutic use!

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