PTEN Mouse Monoclonal Antibody
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AMM5728-11 50ul 1500.00 In Stock
AMM5728-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 5728
Isotype: IgG2a Kappa Swiss Prot: P60484
purity: Affinity purification
Background:
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Reactivity Human
Tested applications WB ELISA IP IF
Clonality Monoclonal Antibody
Calculated MW 54 kDa
Recommended Dilutions
Immunogen PTEN (NP_000305, 2 aa ~ 91 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym BZS, DEC, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del
This product is for research use only, not for diagnostic or therapeutic use!

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