Source: | Rabbit | Gene Id: | 867 |
Isotype: | IgG | Swiss Prot: | P22681 |
purity: | Affinity purification |
Background: |
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
Reactivity | Human |
Tested applications | WB |
Clonality | Monoclonal Antibody |
Calculated MW | 120 kDa |
Recommended Dilutions | |
Immunogen | A synthetic peptide of human CBL is used for rabbit immunization |
Storage | Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles. |
Synonym | C-CBL, CBL2, RNF55 |
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