| No | Size | Price | Availability | |
| AMM5728-61 | 50ul | 1500.00 | In Stock |  |
| AMM5728-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5728 |
| Isotype: | IgG1 | Swiss Prot: | P60484 |
| purity: | Affinity chromatography |
| Background: |
| PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
| Reactivity | Human, Mouse |
| Tested applications | WB ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 54 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human PTEN expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | BZS, MHAM, TEP1, PTEN1 |
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