HAUSP Mouse Monoclonal Antibody
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AMM7874-61 50ul 1500.00 In Stock
AMM7874-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 7874
Isotype: IgG1 Swiss Prot: Q93009
purity: Affinity chromatography
Background:
USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 128 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A purified recombinant fragment of human HAUSP expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym TEF1, HAUSP, USP7
This product is for research use only, not for diagnostic or therapeutic use!

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