| No | Size | Price | Availability | |
| AMM7318-61 | 50ul | 1500.00 | In Stock |  |
| AMM7318-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 7318 |
| Isotype: | IgG1 | Swiss Prot: | P41226 |
| purity: | Affinity chromatography |
| Background: |
| The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. |
| Reactivity | Human |
| Tested applications | WB ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 112 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A purified recombinant fragment of human UBE1L expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | D8, UBE2, UBA1B, UBE1L, MGC12713, UBA7 |
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