| No | Size | Price | Availability | |
| AMM200186-61 | 50ul | 1500.00 | In Stock |  |
| AMM200186-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 200186 |
| Isotype: | IgG1 | Swiss Prot: | Q53ET0 |
| purity: | Affinity chromatography |
| Background: |
| the transducer of regulated CREB protein 2 (TORC2) is a cAMP responsive coactivator that, in concert with LKB1 and AMPK, controls glucose homeostasis in the liver. Under fasting conditions, cytoplasmic TORC2 is transported to the nucleus where it binds to CREB and stimulates gluconeogenisis. Re-feeding and the ensuing insulin response inhibits gluconeogenic gene expression by promoting the phosphorylation, cytoplasmic export and degradation of TORC2. TORC2 is phosphorylated by the kinase QIK which in turn is activated by phosphorylation at Ser358 by insulin-activated Akt2. Phosphorylated TORC2 is subsequently ubiquitinylated at Lys 628 and degraded by the 26S proteasome. TORC2 protein levels and activity are increased in diabetes owing to a block in TORC2 phosphorylation, implicating this pathway in the pathogenesis of diabetes. The CREB/TORC2 regulatory axis controls the normal pattern of germinal center (GC) B cell gene activation/repression that promotes B cell development and circumvents GC lymphomagenesis. |
| Reactivity | Human, Monkey |
| Tested applications | WB IHC ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 80 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human CRTC2 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CREB-regulated transcription coactivator 2, CRTC2, transducer of regulated cAMP response element-binding protein 2, transducer of regulated CREB protein 2 |
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