HIF1A Mouse Monoclonal Antibody
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AMM3091-61 50ul 1500.00 In Stock
AMM3091-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 3091
Isotype: IgG1 Swiss Prot: Q16665
purity: Affinity chromatography
Background:
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. (provided by RefSeq) Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors.
Reactivity Human, Monkey, Mouse
Tested applications WB IHC ELISA ICC
Clonality Monoclonal Antibody
Calculated MW 120 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
Immunogen A purified recombinant fragment of human HIF1A expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym HIF1, MOP1, PASD8, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF1A
This product is for research use only, not for diagnostic or therapeutic use!

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