| No | Size | Price | Availability | |
| AMM284654-61 | 50ul | 1500.00 | In Stock |  |
| AMM284654-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 284654 |
| Isotype: | IgG1 | Swiss Prot: | Q2MKA7 |
| purity: | Affinity chromatography |
| Background: |
| R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. |
| Reactivity | Human |
| Tested applications | WB ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 29 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A purified recombinant fragment of human R-spondin1 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | RSPO1,CRISTIN3,FLJ40906 |
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