Lck Mouse Monoclonal Antibody
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AMM3932-61 50ul 1500.00 In Stock
AMM3932-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 3932
Isotype: IgG1 Swiss Prot: P06239
purity: Affinity chromatography
Background:
Tyrosine kinase that plays an essential role for the selection and maturation of developing t-cell in the thymus and in mature t-cell function. is constitutively associated with the cytoplasmic portions of the cd4 and cd8 surface receptors and plays a key role in t-cell antigen receptor(tcr)-linked signal transduction pathways. association of the tcr with a peptide antigen-bound mhc complex facilitates the interaction of cd4 and cd8 with mhc class ii and class i molecules, respectively, and thereby recruits the associated lck to the vicinity of the tcr/cd3 complex. lck then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (itams) in the cytoplasmic tails of the tcrgamma chains and cd3 subunits, initiating the tcr/cd3 signaling pathway. in addition, contributes to signaling by other receptor molecules. associates directly with the cytoplasmic tail of cd2, and upon engagement of the cd2 molecule, lck undergoes hyperphosphorylation and activation. also plays a role in the il2 receptor-linked signaling pathway that controls t-cell proliferative response. binding of il2 to its receptor results in increased activity of lck. is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-tcr and mature alpha beta tcr.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 56 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A purified recombinant fragment of human Lck expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym EC 2.7.10.2, LCK, LSK, LSK-T, P56-LCK, T cell-specific protein-tyrosine kinase, kinase Lck
This product is for research use only, not for diagnostic or therapeutic use!

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