| No | Size | Price | Availability | |
| AMM9212-61 | 50ul | 1500.00 | In Stock |  |
| AMM9212-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9212 |
| Isotype: | IgG | Swiss Prot: | Q96GD4 |
| purity: | Affinity purification |
| Background: |
| Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines (1-3). Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis (4). The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events (5), and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization (6). |
| Reactivity | Human |
| Tested applications | WB ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 39 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A purified recombinant fragment of human AURKB expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5 |
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