| No | Size | Price | Availability | |
| AMM4921-61 | 50ul | 1500.00 | In Stock |  |
| AMM4921-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 4921 |
| Isotype: | IgG1 | Swiss Prot: | Q16832 |
| purity: | Affinity chromatography |
| Background: |
| DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. |
| Reactivity | Human |
| Tested applications | WB IHC ELISA ICC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 97 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
|
| Immunogen | A purified recombinant fragment of human DDR2 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | TKT, MIG20a, NTRKR3, TYRO10 |
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