MYL3 Mouse Monoclonal Antibody
No Size Price Availability  
AMM4634-61 50ul 1500.00 In Stock
AMM4634-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 4634
Isotype: IgG1 Swiss Prot: P08590
purity: Affinity chromatography
Background:
Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Reactivity Human
Tested applications WB IHC ELISA
Clonality Monoclonal Antibody
Calculated MW 22 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:200-1:1000
Immunogen A purified recombinant fragment of human MYL3 expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CMH8, VLC1, MLC1V, MLC1SB
This product is for research use only, not for diagnostic or therapeutic use!

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