| No | Size | Price | Availability | |
| AMM558-61 | 50ul | 1500.00 | In Stock |  |
| AMM558-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 558 |
| Isotype: | IgG1 | Swiss Prot: | P30530 |
| purity: | Affinity chromatography |
| Background: |
| The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduce signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants. |
| Reactivity | Human |
| Tested applications | WB ELISA ICC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 97 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human AXL expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EC 2.7.10.1AXL oncogene |
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