| No | Size | Price | Availability | |
| AMM3480-61 | 50ul | 1500.00 | In Stock |  |
| AMM3480-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 3480 |
| Isotype: | IgG1 | Swiss Prot: | P08069 |
| purity: | Affinity chromatography |
| Background: |
| IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation. |
| Reactivity | Human |
| Tested applications | WB IHC ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 96 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
|
| Immunogen | A purified recombinant fragment of human IGF1R-Beta expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | IGF1R, IGF1R-Beta |
沪ICP备15003525号 Copyright ©, 2013-2019, Yihyson All Rights Reserved. 
