| No | Size | Price | Availability | |
| ARP546-61 | 50ul | 1500.00 | In Stock |  |
| ARP546-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 546 |
| Isotype: | IgG | Swiss Prot: | P46100 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Reactivity | Human, Mouse |
| Tested applications | IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 282 kDa |
| Recommended Dilutions |
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human ATRX |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EC 3.6.1.-, RAD54L, Transcriptional regulator ATRX, X-linked helicase II, X-linked nuclear protein, XH2, XNP, Znf-HX |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
