| No | Size | Price | Availability | |
| RMM177105-21 | 50ul | 1500.00 | In Stock |  |
| RMM177105-21 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 171105(Rat) |
| Isotype: | IgG1 | Swiss Prot: | P97629 |
| purity: | Affinity purification |
| Background: |
| IRAP (also known as LNPEP) was originally described as an insulin-responsive aminopeptidase found in Glut4-containing vesicles (1). It is essentially always in the same compartments as Glut4 and has identical insulin-stimulated translocation patterns as Glut4 (2). IRAP is therefore considered to be a surrogate marker for Glut4 (2). IRAP was later found to be a critical enzyme that regulates the expression and activity of several essential hormones and regulatory proteins, including the Glut4 transporter (3,4). This membrane associated, zinc-dependent cystinyl aminopeptidase acts as both a receptor for angiotensin IV as well as the enzyme that catalyzes the synthesis of this essential hormone from its angiotensinogen precursor (5). IRAP catalyzes the hydrolysis of several peptide hormones, including oxytocin and vasopressin (4). Abnormal IRAP expression or activity is associated with several forms of cancer in humans, including renal and endometrial cancers (6,7). |
| Reactivity | Mouse |
| Tested applications | WB IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 165 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:1600
|
| Immunogen | A fusion protein corresponding to the amino terminus of rat IRAP |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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