| Source: | Rabbit | Gene Id: | 6195/6196/6197 | 
| Isotype: | IgG | Swiss Prot: | Q15418/P51812/Q15349 | 
| purity: | Affinity purification | 
| Background: | 
| The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3). | 
| Reactivity | Human, Monkey, Mouse, Rat | 
| Tested applications | WB | 
| Clonality | Monoclonal Antibody | 
| Calculated MW | 90 kDa | 
| Recommended Dilutions | WB 1:1000 | 
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser380 of human p90RSK | 
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. | 
| Synonym | / | 
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