| No | Size | Price | Availability | |
| ARM9113P-21 | 50ul | 1500.00 | In Stock |  |
| ARM9113P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9113 |
| Isotype: | IgG | Swiss Prot: | O95835 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 140 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr1079 of human LATS1 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | WARTS, wts |
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